Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratoses

• Status: Not yet recruiting
• Trial end date: 2025-05-22
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to test a new video device for actinic keratoses. The device takes images of your skin lesions during the treatment, to learn whether this device can predict how well the treatment is working.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Case Comprehensive Cancer Center
• Collaborators: National Cancer Institute (NCI); National Institutes of Health (NIH)
• Treatments: Aminolevulinic Acid

Criteria

Inclusion Criteria:

• Participants who have at least 10 Actinic Keratoses lesions on the arms of legs, and with two AK lesions close enough to be seen together within a selected region of interest (ROI)

• Participants must be able to understand and are willing to sign a written informed consent document

Exclusion Criteria:

• Female participants cannot be or become pregnant, nor can be nursing while on this study

• Using any topical treatment on their AKs; must stop at least one month prior

• Currently undergoing treatment for other cancers with medical or radiation therapy

• Patients with a known hypersensitivity to 5-aminolevulinic acid or any component of the study material

• Patients with history of a photosensitivity disease, such as porphyria cutanea tarda