Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers.
Status:
Recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
This is a multi-center study at Washington University (WASH U), University of Southern
California (USC), and Huntington Medical Research Institute (HMRI).The overall goal of both
the AA program and the PPG program is to advance current knowledge on the vascular
contributions to dementia particularly in individuals with the major genetic risk factor for
late-onset AD, i.e., apolipoprotein E-ε4 (APOE4) gene that develop early vascular dysfunction
and significant cerebrovascular pathology compared to non-carriers, and establish whether the
neurovasculature plays a key role in cognitive decline, and therefore is a key new
therapeutic target to treat dementia in APOE4 carriers.
Details
Lead Sponsor:
Tammie L. S. Benzinger, MD, PhD Washington University School of Medicine