Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy

• Status: Recruiting
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid endateriectomy, with reference to pathologic analysis of plaque components

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Caen
• Treatments: Fluorides; Listerine; Sodium Fluoride

Criteria

Inclusion Criteria:

• Age over 18 years old

• Health care system affiliation

• Referred to carotid endarterectomy

• Symptomatic patients:

• Carotid stenosis between 70 and 99% (NASCET criteria)

• TIA or minor stroke attack (RANKIN ≤ 3)

• Asymptomatic patients:

• Carotid stenosis between 70 and 99% (NASCET criteria)

• No symptoms

• Patient who has been informed of the study and has given his/her informed consent

Exclusion Criteria:

• Contra indication to MRI

• Renal failure (clearance < 30ml/mn)

• Patient with active inflammatory disease

• History of cancer

• Pregnancy or lactation

• Patient with carotid disease treated by fibrinolysis

• Patient under guardianship, or unable to understand the purpose of the study