Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
The proposed study will look at cocaine dependent individuals and will consist of three
consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy
will be administered; 2) the 15-21 day inpatient phase (during which participants will start
study medication of levodopa,carbidopa and entacapone (LCE) and will undergo brain imaging
and 3) the 24 weeks outpatient treatment trial. The purpose is to see if treatment with LCE
may reverse baseline brain deficits and if this change is associated with clinical
improvement. Hypothesis is that treatment with LCE, compared to placebo, increases abstinence
from cocaine over a 12-week trial in combination with behavioral treatment with voucher
incentives.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
New York State Psychiatric Institute
Treatments:
Carbidopa Carbidopa, levodopa drug combination Cocaine Entacapone Levodopa