Imatinib Mesylate and Capecitabine in Treating Patients With Advanced Solid Tumors

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving imatinib mesylate together with capecitabine may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of imatinib mesylate when given together with capecitabine in treating patients with advanced solid tumors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herbert Hurwitz
• Collaborator: National Cancer Institute (NCI)
• Treatments: Capecitabine; Imatinib Mesylate

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant solid tumors for which no standard effective therapy exists OR such therapy is refused

• Previously treated brain metastases that are currently asymptomatic allowed

PATIENT CHARACTERISTICS:

Performance status

• Karnofsky 70-100%

Life expectancy

• Not specified

Hematopoietic

• Absolute neutrophil count > 2,000/mm^3

• Platelet count > 100,000 mm^3

• Hemoglobin > 9.0 g/dL

Hepatic

• Alkaline phosphatase < 2.5 times upper limit of normal (ULN)

• SGOT and SGPT < 2.5 times ULN

• Bilirubin < 1.5 times ULN

Renal

• Creatinine clearance > 50 mL/min

Cardiovascular

• No congestive heart failure

• No symptomatic coronary artery disease

• No uncontrolled cardiac arrhythmias

• No myocardial infarction within the past 12 months

• No other clinically significant cardiac disease

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 3 months after completion of study treatment

• No prior unanticipated severe reaction to fluoropyrimidine therapy

• No known sensitivity to fluorouracil

PRIOR CONCURRENT THERAPY:

Biologic therapy

• More than 28 days since prior biologic therapy

Chemotherapy

• More than 28 days since prior chemotherapy (42 days for nitrosoureas or mitomycin C)

Endocrine therapy

• At least 90 days since prior steroids for the treatment of brain metastases

• More than 28 days since prior hormonal therapy

Radiotherapy

• At least 90 days since prior radiotherapy for the treatment of brain metastases

• More than 28 days since other prior radiotherapy

• No prior pelvic radiotherapy > 30% of the bone marrow

Surgery

• More than 28 days since prior surgery and recovered