Imatinib in Patients With Desmoid Tumor and Chondrosarcoma

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Imatinib Mesylate is active in diseases - such as Desmoid Tumor and Chondrosarcoma - expressing the receptor for the platelet-derived growth factor (PDGF) both in its isoform alpha and beta

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Italian Sarcoma Group
• Treatments: Imatinib Mesylate

Criteria

Inclusion Criteria:

• Histological diagnosis of DT or CDS.

• Biomolecular or immunohistochemical evidence of Imatinib mesylate target (KIT, PDGFRα PDGFRβ activation and/or presence of PDGFα or PDGFβ)

• Measurable or evaluable disease

• Surgical resection of local disease unfeasible radically (or unaccepted by the patient, or amenable to become less demolitive, or easier, or likely more feasible, after cytoreduction) and/or metastatic disease.

• ECOG Performance status 0, 1, 2 or 3

• Adequate bone marrow, liver and renal function

• Female patients of child-bearing potential must have negative pregnancy test.

• Male and female patients of reproductive potential must agree to employ an effective method of birth control throughout the study.

• Written, voluntary, informed consent.

Exclusion Criteria:

• Previous treatment with any other investigational or not investigational agents within 28 days of first day of study drug dosing

• Other primary malignancy with <5 years clinically assessed disease-free interval, except basal cell skin cancer or cervical carcinoma in situ.

• Grade III/IV cardiac problems as defined by the New York Heart Association Criteria

• Severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection)

• Known brain metastasis.

• Known chronic liver disease (i.e., chronic active hepatitis, and cirrhosis).

• Known diagnosis of human immunodeficiency virus (HIV) infection.

• Previous radiotherapy to >/=25% of the bone marrow or within the previous 2 months on target lesion.

• Major surgery within 2 weeks prior to study entry.

• Expected non-compliance to medical regimens (e.g. psychiatric diseases).