Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis

• Status: Unknown status
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with PROM later than the 37+0 weeks of gestation. The secondary aim is to compare the rates of infection between immediate and delayed induction in women submitted to antibiotic prophylaxis.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital de Santa Maria, Portugal
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefoxitin; Misoprostol; Oxytocin

Criteria

Inclusion Criteria:

• term (≥ 37+0 weeks) singleton pregnancy, a vertex presentation, ruptured membranes for less than 12 hours and a negative Group B Streptococcus (GBS) culture performed between 35 and 37 weeks.

Exclusion Criteria:

• active labor, absence of GBS culture or indication for GBS antibiotic prophylaxis, contraindication to expectant management or to vaginal delivery