Fibromyalgia is a common condition in clinical medical practice, characterized by diffuse
musculoskeletal pain. Sleep disorders, chronic fatigue, depression, intestinal disorders and
headache are also commonly associated with the syndrome .
Although the etiology of this syndrome is not well defined yet, it means involve multiple
mechanisms, including low levels of serotonin, increased substance P in cerebrospinal fluid
and altered circadian variation in sympathetic - parasympathetic balance, consistent with
changes in sympathetic hyperactivity at night .
The immune - pineal system, formed by the integration of the adrenergic and immune systems
pineal gland, appears to be involved in the genesis of the dysfunctions found in
fibromyalgia. Melatonin is secreted by the pineal gland and has promoter activity of sleep.
Studies show that melatonin and its precursors , serotonin and tryptophan are reduced in
patients with fibromyalgia.
The present study aims to evaluate the relationship of immune - pineal system in the process
of fibromyalgia , since dysfunction of this axis appears to govern the cascading events that
participate in the pathophysiological process of this disease.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination Melatonin