Immune Response of Caudally Administrated Tramadol In Pediatric Lower Abdominal Surgery
Status:
Completed
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
Management of acute pain is one of the most important tasks of perioperative pediatric
anesthesia. The alleviation of pain has been defined by the Society of Pediatric Anesthesia,
on its 15th annual meeting as a basic human right, irrespective of age, treatment primary
service responsible for the patient care. Pro-inflammatory cytokines increased by surgical
trauma indirectly modulate pain through the release of substances like nitric oxide, oxygen
free radicals, prostaglandins, and excitatory amino acids, inducing peripheral and central
sensitivity and hyperalgesia. There has been growing interest in determining the possible
immune consequences of analgesic administration for the management of postoperative pain