Immunomodulatory Effect of Dexmedetomidine as an Adjuvant Drug in Laparoscopic Cholecystectomies
Status:
Recruiting
Trial end date:
2022-10-31
Target enrollment:
Participant gender:
Summary
Trauma triggers a tissue response involving the central nervous system, the
hypothalamic-pituitary-adrenal axis and the immune system. There are many surgical and
anesthetic factors that affect the response to trauma, and the control of the inflammatory
factor is considered the most important. (KÜÇÜKEBE, O.B. ET AL, 2017). Dexmedetomidine is a
specific α2-adrenergic agonist. By direct action on the sympathetic nervous system,
α2-adrenergic agonists can exert beneficial effects on the immune system through neuroimmune
interactions. Its administration can induce an anti-inflammatory response due to different
central (increase parasympathetic tone, promoting control of the inflammatory condition) and
peripheral effects (stimulating innate immunity). (MILLER, 2015). This study aims to evaluate
the effect of dexmedetomidine administration in association with general anesthesia in a
medium-sized surgical model, videolaparoscopic cholecystectomy.