Overview

Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer

Status:
Recruiting
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
This clinical trial will be conducted as a single-center, open-label, Phase I/2 trial to evaluate the feasibility and safety of Yttrium-90 radioembolization (Y90-RE) in combination with a fixed dose of of immunotherapy (durvalumab - 750 mg) in subjects with liver-predominant, metastatic colorectal cancer (mCRC), which is mismatch repair proficient/microsatellite stable (pMMR/MSS).
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Chandrikha Chandrasekharan
University of Iowa
Collaborators:
AstraZeneca
Biocompatibles UK Ltd
Treatments:
Antibodies, Monoclonal
Atezolizumab
Durvalumab
Immunologic Factors
Methamphetamine