Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Status:
Terminated
Trial end date:
2005-12-01
Target enrollment:
Participant gender:
Summary
Critically ill patients are generally exposed to an increased oxidative stress, which is
proportional to the severity of their condition. Endogenous antioxidant (AOX) defenses are
depleted particularly in those patients with intense inflammatory response. The hypothesis
tested is that early I:V: administration of a combination of AOX micronutrient supplements
(Se, Zn, Vit C, Vit E, Vit B1) would improve clinical outcome in selected critically ill
patients, by reinforcing the endogenous AOX defenses and reducing organ failure.
Phase:
Phase 3
Details
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Collaborator:
Fresenius Kabi
Treatments:
Antioxidants Selenium Thiamine Vitamin E Vitamins Zinc