Overview

Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome

Status:
Terminated

Trial end date:
2005-12-01

Target enrollment:
0

Participant gender:
All

Summary

Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition. Endogenous antioxidant (AOX) defenses are depleted particularly in those patients with intense inflammatory response. The hypothesis tested is that early I:V: administration of a combination of AOX micronutrient supplements (Se, Zn, Vit C, Vit E, Vit B1) would improve clinical outcome in selected critically ill patients, by reinforcing the endogenous AOX defenses and reducing organ failure.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Centre Hospitalier Universitaire Vaudois

Collaborator:

Fresenius Kabi

Treatments:

Antioxidants
Selenium
Thiamine
Vitamin E
Vitamins
Zinc

Criteria

Inclusion Criteria:

- adult patients admitted for above diagnosis assessed on admission by the medical team
likely to require more than 48 hours of ICU

Exclusion Criteria:

- absence of consent, participation in another study, liver cirrhosis or major burns and
life expectancy < 24 hours or a lack of commitment to full aggressive care
(anticipated withholding or withdrawing treatments in the 48 hours