Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes
• Treatments: Amikacin; Gentamicins

Criteria

Inclusion Criteria:

• ICU patient with severe sepsis

• Treated with aminoglycosides

Exclusion Criteria:

• Renal replacement therapy

• Allergy to aminoglycosides

• Confirmed and/or suspected to have myasthenia

• ICU-acquired neuromuscular disorder

• Under guardianship

• Prisoners

• The patient has already participated in the present protocol