Impact of Angiotensin Converting Enzyme Activity on Exercise Training Sensitivity
Status:
Completed
Trial end date:
2019-12-30
Target enrollment:
Participant gender:
Summary
The phenotype based on the insertion/deletion (I/D) polymorphism of the human angiotensin
converting enzyme (ACE) gene has been associated with individual training response. Briefly,
intervention studies have demonstrated an 11-fold greater training-induced improvement in
muscular endurance for ACE I/I homozygotes compared to ACE D/D homozygotes.
Importantly, the ACE I/D polymorphism causes large inter-individual differences in serum ACE
activity. Because the ACE D/D genotype is characterized by high plasma ACE activity and
potentially blunted endurance exercise training response, it appears likely that ACE
inhibitors (ACEi) have the potential to improve the outcome of exercise training for ACE D/D
homozygotes.
Thus, in the present study the investigators apply a randomized double-blind
placebo-controlled longitudinal design to investigate whether pharmacological inhibition of
ACE activity can amplify the exercise training response in healthy humans carrying either the
ACE D/D or ACE I/I genotype.
The study hypothesis is that inhibition of ACE activity in healthy humans with the ACE D/D
genotype will amplify the health beneficial effects of exercise training while this is not
the case in ACE I/I homozygotes.