Impact of Aripiprazole on Postoperative Analgesia in Laparoscopic Hysterectomy

• Status: Active, not recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The analgesic effect of perioperative use of aripiprazole has not been fully investigated.

So, this study aims to test the effects of aripiprazole versus placebo in reducing postoperative pain following laparoscopic hysterectomy and to explore the potential side effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Aripiprazole

Criteria

Inclusion Criteria:

• Physical status American Society of Anesthesiologist (ASA) I or II

• Electively scheduled for laparoscopic hysterectomy,

Exclusion Criteria:

• Patients who refuse to participate

• Body mass index (BMI) > 30

• ASA physical status > II

• Diabetes

• Major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological)

• Coagulation abnormalities

• Pregnancy

• Known hypersensitivity to aripiprazole or contraindications to its use (a psychiatric illness, patients on antidepressants, dementia-related psychosis)

• History of drug addiction or alcohol abuse

• Mental retardation interfering with the evaluation of pain scores or PCA programs .