Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study

• Status: Unknown status
• Trial end date: 2021-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The study is to investigate the impact of blood glucose management at the first trimester of pregnant women with gestational diabetes on the maternal and fetal outcomes and metabolic disorder.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University
• Treatments: Insulin; Insulin, Globin Zinc; Isophane Insulin, Human

Criteria

Inclusion Criteria:

• regular antenatal examination from the first trimester;

• accurate left mentoposterior(LMP) verified by ultrasonography(USG);

• fasting blood glucose level between 5.1 mmol/L and 7.0 mmol/L.

Exclusion Criteria:

• younger than 18 years old;

• do not give birth in the research centers above;

• LMP is undefined and lack of USG during 6-14 gestational weeks;

• multiple pregnancy;

• non-natural pregnancy(including intrauterine insemination(IUI), in-vitro fertilization and embryo transfer(IVF-ET), etc);

• diagnosed DM before pregnancy;

• with hepatitis B virus, hepatitis C virus, HIV infection;

• taking drugs including glucocorticoid, diuretic, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker(ACEI/ARB), etc.

• complicated with diseases that affect glucose metabolism such as hyperthyroidism and so on.