Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease

• Status: Completed
• Trial end date: 2017-11-02
• Target enrollment: 0
• Participant gender: All

Summary

Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care. In recent studies a new innovative MRI-technique that can detect changes in oxygen supply of the heart was able to show that the administration of oxygen or fast breathing can decrease the blood supply of the arteries supplying the heart muscle with oxygen. Thus, the administration of oxygen may paradoxically impair the oxygen supply of the heart muscle. In this study the investigators want to investigate, whether the administration of exogenous oxygen via a mask alone and in combination with fast breathing leads to a decrease in oxygen supply in regions with already impaired blood supply by a narrowing of a coronary artery of the heart.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Inselspital, Berne

Criteria

Inclusion Criteria:

• Patients with known relevant coronary artery stenosis (defined by previous coronary angiography, QCA: reduction in lumen-diameter of the vessel >50%) with a scheduled intervention or operation to treat this stenosis (staged PCI or coronary artery bypass surgery)

• CMR feasible prior to intervention or surgery

• Age ≥18 years

• Written informed consent

• For healthy participants: Absence of cardiovascular and lung disease, and absence of medication with cardiovascular effects

• Absence of exclusion criteria

Exclusion Criteria

• General Contraindication against MRI-Scans: (claustrophobia, ferromagnetic implants, clips, pacemakers, shrapnels, ophthalmic metal deposits)

• Pregnancy or inconclusive test result

• Age <18 years

• Inability to give informed consent

• Consumption of caffeine, tea, treatment of dipyridamol <12h before the scan

• Medication with calcium antagonists (ok, if can be paused on the day of the scan)

• Constant medication with nitrates (ok, if can be paused on the day of the scan)

• Medication with methyl-xanthines

• Acute myocardial ischemia/myocardial infarction

• Previous Coronary Bypass Surgery

• Pulmonary Disease

• Enrolment of the investigator, his/her family members, employees and other dependent persons

• Presence of cardiac or lung disease for healthy volunteers, nicotine consumption within the last 6 months