Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts
have yielded behavioral interventions that reduce cocaine use, however, these interventions
are not universally effective and treatment effects diminish over time. Development of a
pharmacotherapy that enhances the efficacy of these interventions is a priority for the
National Institute on Drug Abuse. This study proposes to determine the impact of buspirone
maintenance on self-administration of cocaine and alternative reinforcers. These preliminary
data will be used to support further research developing buspirone as a pharmacotherapy for
cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects
of cocaine and increase the reinforcing effects of alternative reinforcers.