Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function

• Status: Not yet recruiting
• Trial end date: 2024-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University Medical Center
• Collaborator: Merck Sharp & Dohme LLC
• Treatments: Bromides; Rocuronium

Criteria

Inclusion Criteria:

• Age of 18 years or older

• Scheduled for total hip replacement surgery under general anaesthesia

• Informed consent obtained

Exclusion Criteria:

• Insufficient control of the Dutch language to read the patient information and to fill out de questionnaires

• Known or suspected hypersensitivity to rocuronium or sugammadex

• Deficiency of vitamin K dependent clotting factors or coagulopathy

• Severe renal disease (creatinine clearance <30 ml/min), including patients on dialysis

• Severe liver disease (Child-Pugh Classification C)

• Known or suspected neuromuscular disorders impairing neuromuscular function

• Women who are or may be pregnant or currently breastfeeding

• Chronic use of psychotropic drugs

• Use of immunomodulatory medication