Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In critically ill patients, a strategy aimed at an early delivery of full caloric support, with a combination of Enteral Nutrition (EN) and Parenteral Nutrition (PN) (in conditions preventing hyperglycemia and overfeeding), results in shorter ICU and hospital stay and less morbidity as compared to a strategy using only EN.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Katholieke Universiteit Leuven; KU Leuven
• Collaborators: Baxter Healthcare Corporation; Fund for Scientific Research, Flanders, Belgium

Criteria

Inclusion Criteria:

1. Patients admitted to any of the five intensive care units

2. Older than 18 years

3. Nutritional risk screening score (NRS) higher or equal to three upon ICU admission

Exclusion Criteria:

1. Patients with a do not resuscitate (DNR) code or moribund at the time of ICU admission

2. Patients already enrolled in another trial

3. Patients transferred from another intensive care unit with an established nutritional therapy

4. Patients suffering from ketoacidotic or hyperosmolar coma on admission

5. Patients with a body mass index (BMI) below 17 kg/m^2

6. Short bowel syndrome

7. Patients known to be pregnant or nursing

8. Patients on mechanical ventilation at home

9. NRS score lower than three

10. Patient readmitted to ICU after randomization to the EPaNIC trial.

11. Patient not critically ill on admission. (No clinical indication for central intravenous catheter or patient ready for oral nutrition on admission.)