Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells

• Status: Not yet recruiting
• Trial end date: 2022-11-30
• Target enrollment: 0
• Participant gender: Female

Summary

To study the influence of different daily rec-FSH dosages (150 IU versus 300 IU), performed in the same patient in consecutive cycles, on the relation between FSH- and LH-receptors of the granulosa cells of the growing follicle.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: ART Fertility Clinics LLC
• Collaborator: Organon and Co
• Treatments: Follicle Stimulating Hormone

Criteria

Inclusion Criteria:

• Desire to perform oocyte freezing for social fertility preservation, age 18 - 38 years

• BMI of 18-32 kg/m2

• Regular menstrual cycles with a length of 24-35 days

• Anti-Muellerian-Hormone levels between 1.3 - 6.25 ng/ml (Ferraretti and Gianaroli, 2014; Calzada et al., 2019)

Exclusion Criteria:

• Occurrence of ovarian hyperstimulation syndrome (OHSS)

• Occurrence of poor ovarian response (AFC < 5 and AMH < 0,5ng/ml) in previous ovarian stimulation treatment (20)

• Polycystic ovary syndrome (PCOS) (21)