Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser

• Status: Not yet recruiting
• Trial end date: 2026-03-15
• Target enrollment: 0
• Participant gender: All

Summary

In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous hydration, which has never before been the subject of a specific analysis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Tours
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• Patients ≥ 18 years old and < 80 years old

• With the need to perform a flexible ureteroscopy with destruction of the kidney stones with laser

• Participants covered by or entitled to social security

• Written informed consent obtained from the participant

• Ability for participant to comply with the requirements of the study

Exclusion Criteria:

• Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal protection measure: guardianship or trusteeship)

• Contra-indication to Furosemide:

• Hyper-sensitivity to the active substance or one of the excipients

• Hyper-sensitivity to Sulfonamide

• Renal failure with oligo-anuria refractory to Furosemide

• Hypokalemia < 3,5 mmol/L

• Severe hyponatremia

• Hypovolemia with or without hypotension or dehydration

• Ongoing hepatitis, hepatic insufficiency severe and hepatic encephalopathy

• Patient having Furosemide as usual treatment

• Patient requiring an injection of Aminoside or Vancomycin before or during the procedure

• Participation in other interventional research with an investigational drug or medical device