Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free days) in critically ill patients, a university hospital, Thailand.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Gabapentin

Criteria

Inclusion Criteria:

• Adults (18 years and older)

• Patients admitted to ICU not more than 24 hours at the time of randomization

Exclusion Criteria:

• Patients admitted to ICU less than 72 hours

• Patients receiving gabapentin within 14 days prior to randomization

• Patients receiving restorative drug (trazodone, mirtazapine, olanzapine, agomelatine, and pregabalin) within 7 days prior to randomization

• Patients having contraindications to gabapentin

• Patients receiving high dose vasopressors more than 1 hour during ICU admissions

• Patients presenting with severe respiratory failure (PF ratio < 100)

• Patients presenting with RASS < -2 at the time of randomization

• Patients having target RASS of <-2 during ICU admissions

• Terminal ill patients

• Pregnancy