Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction

• Status: Active, not recruiting
• Trial end date: 2023-01-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia
• Treatments: Insulin

Criteria

Inclusion Criteria:

• healthy adult men and women;

• 18-45 years of age;

• BMI 18-30 kg/m2;

• non-pregnant/non-breastfeeding;

• non-nicotine users;

Exclusion Criteria:

• taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions

Self-reported history of:

• hepatic, renal, pulmonary, cardiovascular, or neurological disease;

• stroke or neurovascular disease;

• bleeding/clotting disorders;

• sleep apnea or other sleep disorders;

• diabetes;

• smoking;

• history of alcoholism or substance abuse, excessive alcohol consumption;

• hypertension;

• active cancer;

• autoimmune disease;

• immunosuppressant therapy