Overview

Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

Status:
Not yet recruiting
Trial end date:
2027-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia.
Phase:
Phase 2
Details
Lead Sponsor:
Rong Zhang
Collaborators:
Michigan State University
National Institute on Aging (NIA)
Texas Health Resources
Treatments:
Amlodipine
Angiotensin II
Angiotensin Receptor Antagonists
Angiotensinogen
Calcium
Calcium Channel Blockers
Giapreza
Losartan