Impact of Intraoperative Deep Neuromuscular Blockade on NOL-guided Opioid Requirement in LSC Colorectal Surgeries

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to answer the question whether deep neuromuscular blockade has a clinically significant impact on intra and postoperative pain, opioid requirement and anesthesia related outcomes and side effects for the early phase of recovery (24hs) after colorectal laparoscopic surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ciusss de L'Est de l'Île de Montréal
• Collaborator: Merck Canada Inc.
• Treatments: Analgesics, Opioid; Rocuronium

Criteria

Inclusion Criteria:

• ASA1-3 patients,

• fully consented,

• primary colorectal laparoscopic surgery and no previous laparotomy for the last 5 years

• BMI < 35,

• Age > 18yo,

• no allergy to any of the medications used in this study.

Exclusion Criteria:

• history of coronary artery disease

• serious cardiac arrhythmia (including atrial fibrillation)

• history of substance abuse

• chronic use of psychotropic and/or opioid drugs

• use of drugs that act on the autonomic nervous system (including β-blockers)

• history of psychiatric diseases with the need of medication

• allergy to any drug used in the study protocol

• refusal of the patient for participation in the study