Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
Status:
Completed
Trial end date:
2018-09-30
Target enrollment:
Participant gender:
Summary
During major surgical procedures, intravascular volume is maintained with the administration
of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three
of these fluids are in common clinical use for this purpose. As large volumes of NS may
result in a dilutional acidosis and an increasing base deficit, it may cloud clinical
decision making when resuscitative efforts are guided by acid-base status on routine arterial
blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base
and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids
for intraoperative resuscitation.