Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
After obtaining approval from the Institutional Review Board of our institution, written
informed consent is obtained from patients undergoing interventional cerebral aneurysm
coiling procedure are enrolled in this prospective study and randomly allocated into one of
two groups: Group-C (n=10) and Group-HES (n=10).
All recruited patients will be given patient identification number (PIN) for the present
study of 01-20 according to their order of interview and recruitment. Investigators will
prepare 10 yellow and 10 green cards, which will be inserted in 20 thick-paper envelopes.
Then, all envelopes will be sealed, mixed and randomly allocated to get numbers of 01 to 20
(Envelop number). After printing the envelope number outside envelope, all sealed envelopes
with cards will be conveyed to and kept in pharmacy department.
According to the color of the card, attending anesthesiologists will give crystalloid for
yellow card or HES for green cards, respectively, to maintain stroke volume variation < 15
during volume controlled ventilation (8 ml/kg tidal volume) of O2/air mixture.
Patient data and statistical analyses:
Patient's data whole blood viscosity, PaO2, FiO2, Hemoglobin, urine amount, s-glucose will be
determined from the patients' medical record after patient's discharge.
All statistical analyses will be performed after the 20th patient's discharge and data
acquisition