Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production
Status:
Recruiting
Trial end date:
2023-12-12
Target enrollment:
Participant gender:
Summary
Chronic kidney disease (CKD) is associated with accumulation of uremic toxins like p-cresyl
sulfate and indoxyl sulfate that are associated of cardiovascular complication and
perturbation of glucose metabolism. These toxins are produced by fermentation of protein by
intestinal microbiota but the role of low protein diet and ketoanalogue supplementation on
uremic toxins production and microbiota composition are unknown. Low protein diet
supplemented with ketoanalogues is recommended inCKD patients to prevent progression of renal
disease. The aim of this study is to determine the impact of uremic toxins concentration,
microbiota composition and gut hormone involved in carbohydrate metabolism ( GLP-1, FGF19,
bile acids) with low protein diet supplemented with ketoanalogues.