Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
The Transesophageal Echocardiography (TEE) Surgical Treatment of Ischemic Heart Failure
(STICH) ancillary study will define the mechanism(s) of functional mitral regurgitation (MR)
by TEE in patients with ischemic cardiomyopathy, and the impact of therapy (medical, coronary
artery bypass grafting [CABG], or CABG plus surgical ventricular restoration [SVR]) on
mechanism and severity of MR. Severity of the effect of functional MR on clinical outcomes
will also be examined. The TEE STICH study will address four specific aims that will focus on
defining the following: 1) the mechanism(s) of functional MR in ischemic cardiomyopathy; 2)
the effect of therapy on the mechanism and severity of functional MR; 3) myocardial viability
on functional MR and its response to treatment; and 4) the effect of MR on prognosis in
ischemic cardiomyopathy.