Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes
Status:
Recruiting
Trial end date:
2025-02-02
Target enrollment:
Participant gender:
Summary
Vascular calcification (VC) is a complication frequently observed in elderly, in chronic
kidney disease (CKD) and in diabetes (particularly in type 1 diabetes). VC is a dynamic
pathophysiological process that causes cardiovascular morbidity and is an independent risk
factor of major amputation. In vitro and human observational studies have suggested a role of
metformin in preventing VC. The investigators propose to test the effect of metformin
treatment during two years on lower limb arterial calcification evaluated by CT-scan in
patients with type 1 diabetes and without CKD.
This research is a phase III double blind randomized controlled trial consisting of 2 years
double-blind treatment phase (patients randomized to metformin or placebo) in type 1 diabetic
patients.
The participants and the investigators will be blinded to the study medications taken during
the double-blind treatment period