Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients

• Status: Completed
• Trial end date: 2019-07-30
• Target enrollment: 0
• Participant gender: All

Summary

1. Assess the impact of midodrine administration on weaning of IV vasopressors

2. Assess the cost effectiveness of using midodrine in critically ill patients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Midodrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

1. Adult patients (18-80)years

2. Hypotensive (systolic blood pressure<90mm Hg)and require IV vasopressor for more than 24 hours

3. Require IV vasopressor at rate < 8mcg/min and unable to wean for >24 hours

Exclusion Criteria:

1. Severe organic heart disease (ejection fraction <30 percent due to higher risk of arrythmia)

2. Bradycardia (HR<50 b/m)due to higher likelihood of symptomatic bradycardia

3. Chronic kidney disease (serum creatinine >2mg/dl) as midodrine and its active metabolites are almost completely execreated in urine

4. Thyrotoxicosis

5. Known allergy to midodrine