Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can
lead to bone destruction and tooth loss. Several studies had been reported the association to
periodontal disease with systemic conditions and this relation suggests and axis that links
oral and gut microbiome. In order to clarify the impact of periodontal condition on gut
microbiome, we aim to evaluate the clinical, immunological parameters and the microbiological
condition by sequencing of subgingival biofilm and stool samples both before and after
non-surgical periodontal treatment with and without antibiotics as adjunct.