Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults

• Status: Withdrawn
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor associated with long-term mortality among different patient populations. Renal dysfunction and subsequent chronic kidney disease is implicated in the development of hypertension and cardiovascular disease. The investigators overall hypothesis is that, in the pediatric population, sepsis-related AKI will have unrecognized, long-term consequences with regard to kidney function, endothelial function, blood pressure control, and overall health.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Florida
• Collaborator: American Society of Nephrology

Criteria

Inclusion Criteria:

For all patients:

• Age 18-24 at time of participation in the study

For non-AKI sepsis patients:

• Hospitalization with a diagnosis of sepsis from 1998-2014

• Failure to meet pEDRIFLE criteria for AKI during incident sepsis admission

• Participation in cognitive survey study with completion of the PedsQL survey

For sAKI patients:

• Hospitalization with a diagnosis of sepsis from 1998-2014

• Severe AKI as defined by the pEDRIFLE criteria during incident sepsis admission

• Participation in cognitive survey study with completion of the PedsQL survey

Exclusion Criteria:

For all patients:

• Known pre-existing CKD as defined by history of kidney transplant or long-term dialysis

• Age greater than 18 years at the time of incident sepsis admission

• AKI from primary kidney disease including acute glomerulonephritis and obstructive uropathy

• Pregnancy at the time of enrollment

• Known or suspected allergy to gadolinium based contrast

• Known or suspected allergy to iodine or shellfish will be excluded from RPF measurement with iodohippurate

• Heart failure or condition whereby the administration of 0.9% normal saline would be contraindicated