Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Periodontitis is an inflammatory/infectious disease of high prevalence in the population and which has been linked to several chronic inflammatory systemic diseases. However, few studies have evaluated the periodontal disease in the absence of other inflammatory conditions stimulate inflammatory markers as C-reactive protein (CRP), Interleukin - 6 (IL-6) hepcidin and hemoglobin. The aim of this study was to evaluate the influence of nonsurgical periodontal therapy on the change of inflammatory markers and anemia in control subjects and patients with chronic periodontitis after three months.This interventional study included 67 individuals of both sexes, aged 30-65 years, without other diseases, except chronic periodontitis, with at least 20 teeth, selected from a total 125 individuals following the eligibility criteria. Periodontal clinical parameters (probing depth, bleeding on probing, clinical attachment level) and systemic, hematological as well as inflammatory markers CRP, IL-6 and hepcidin were compared before and after nonsurgical periodontal therapy by serum and plasma examination of control individuals and patients with chronic periodontitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Federal University of Maranhao
• Treatments: Albendazole; Hepcidins

Criteria

Inclusion Criteria:

• Both sexes

• Aged 30-65 years

• Without other chronic systemic diseases except periodontitis

• At least 20 teeth

Exclusion Criteria:

• Diabetes mellitus

• Congestive heart failure

• Chronic kidney disease

• Malignant neoplasms

• Acquired immunodeficiency syndrome

• Hypertension

• Pregnant women

• Nursing mothers

• Immunosuppressed by medication

• Women with changes in menstrual flow

• Smokers or ex-smokers for less than 10 years

• Usage history of NSAIDs or nonsteroidal and antibiotics within 3 months prior to the study and during the search

• Iron replacement in patients to treat anemia and carrying out subgingival scaling and periodontal surgery in 6 months prior to investigation.