Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia

• Status: Suspended
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall purpose of this study is to characterize the effect of probiotics on the oral microbiota in older adults with dysphagia at risk for pneumonia.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison

Criteria

Inclusion Criteria

1. 65 years of age or older

2. Dysphagia diagnosis based on videofluoroscopic swallow study with observed airway invasion (Penetration-Aspiration Scale score of 3 or higher)

3. Ability to provide consent

4. Ability to submit oral samples

5. Ability to swallow sachet of probiotic (dissolved in thickened liquid, as needed)

6. Ability to return to UWHC for week 2 and week 4 visits.

Exclusion Criteria

1. Currently taking antibiotics or probiotics

2. Actively receiving immunosuppressive therapy

3. Non-oral feeding with inability to swallow probiotic

4. diagnosis of head and neck cancer or upper airway disease

5. prior surgery to the head and neck region that would have affected the muscles of swallowing or the salivary glands

6. history of chemotherapy or radiation to the head and neck region

7. severe periodontal disease.

8. currently pregnant or planning to become pregnant