Impact of Propofol Versus Sevoflurane on Incidence of Postoperative Delirium in Elderly Patients After Spine Surgery

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative delirium in older adults is a common and costly complication after surgery. Propofol and sevoflurane are commonly used anesthetics to maintain sedation during spine surgery, and have different sedative and anti-inflammatory effects. The aim of this trial will be compare the impact of propofol versus sevoflurane on incidence of postoperative delirium in elderly patients after spine surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Qianfoshan Hospital
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

1. age ≥65 years and ≤90 years;

2. scheduled to undergo surgery for spinal, under general anaesthesia;

3. American Society of Anesthesiology (ASA) I-III;

4. agree to participate, and give signed written informed consents.

Exclusion Criteria:

1. family history or history of malignant hyperthermia;

2. History of propofol or sevoflurane allergy;

3. demonstrated cognitive impairment on the modified Mini-Mental State Examination (score, <24of 30 or <20 of 30 if the patient's education year was less than 6 years or<17 if the patient is Illiterate);

4. planned postoperative intubation or transferred to ICU;

5. severe visual or auditory handicap;

6. prior diagnoses of neurologic diseases or mental disorders (e.g., stroke, Parkinson's disease, dementia, schizophrenia, or depressive illness)

7. take anticholinergic drugs or other drugs acting on the central nervous system for a long time before operation

8. participating in other clinical studies in recent 3 months