Impact of Rosuvastatin on Endothelial Function and Inflammation in Patients With Chronic Heart Failure
Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
Participant gender:
Summary
Statin therapy has been shown to efficiently reduce mortality in patients with coronary
artery disease and myocardial infarction, partially as a result of the lipid-lowering
properties of statins. However, especially the pleiotropic effects of statins, e.g. their
anti-inflammatory and anti-oxidative properties, might be of interest in the treatment of
patients with chronic heart failure that are limited in their exercise capacity due to
alterations of the skeletal muscle and peripheral endothelial dysfunction.
Aim of this trial is therefore to assess the effects of three months of rosuvastatin
treatment on markers of inflammation and oxidative stress in the skeletal muscle and the
blood, on postnatal vasculogenesis, and endothelial function of the radial artery in patients
with severe chronic heart failure.