Impact of Ticagrelor Re-load on Pharmacodynamic Profiles
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Platelets are parts of your blood that stick together to help form a clot. The stickier your
platelets are, the greater your chance of having a heart attack. A clot in the wrong place
can lead to a heart attack or stroke. Ticagrelor (Brilinta) keeps platelets from sticking
together and it helps people from having a heart attack. The American College of Cardiology
has recommended a combination of aspirin and Brilinta as one of the best treatments for the
prevention of heart attacks, and death in patients who have had a heart attack or coronary
stents. However, it is unknown if Brilinta may improve its work to keep platelets from
sticking together giving a loading dose in patients already treated with Brilinta. A loading
dose is a one-time increased dose of the same drug. The purpose of this study is to
demonstrate whether the platelets of patients treated with Brilinta become less sticky when
Brilinta is re-loaded.