Impact of Tramadol and Oxycodone on Sleep Apnea

• Status: Completed
• Trial end date: 2020-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative pain is usually treated with opioids. Among them, oxycodone is popular in the daily practice as it is administered orally and is easily titrated. However, side-effects include increase duration and frequency of apneic episodes. Some authors believe that tramadol has less impact on these apneic episodes during the first postoperative night, based on a trial that reported conclusive results only during the first 2 postoperative hours. The objective of this randomized controlled trial is to compare the effect of postoperative pain treatment of oxycodone with tramadol on apneic episodes during the first and third postoperative nights.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire Vaudois
• Treatments: Oxycodone; Tramadol

Criteria

Inclusion Criteria:

• patients scheduled for orthopaedic surgery on the lower limb under a spinal anaesthesia

• physical status I-III

Exclusion Criteria:

• planned surgical duration more than 3 hours

• contraindication to spinal anaesthesia

• severe respiratory disease

• patient treated for sleep apnea syndrome

• allergy to tramadol or oxycodone