Impact of Uterotonic Agents on Isolated Human Myometrium

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs. The drugs studied are typically used to contract the uterus when a pregnant patient continues to bleed after delivery. Amongst the uterotonic drugs (used to contract the uterus), namely oxytocin, ergonovine and carboprost, the most effective one to use is not known.

The investigators will be testing uterine muscle samples in the presence of these drugs at various concentrations, to see what their contractility measures over time, as compared with a control sample, in which no drugs will be applied.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
• Treatments: Carboprost; Carboprost tromethamine; Ergonovine; Oxytocin

Criteria

Inclusion Criteria:

• Gestational age 37-41 weeks

• Non-laboring patients, not exposed to exogenous oxytocin

• Patients requiring primary Cesarean section

• Cesarean section under spinal anesthesia

Exclusion Criteria:

• Patients who require general anesthesia

• Patient who had previous uterine surgery or Cesarean section

• Patients with placental anomalies

• Emergency Cesarean section in labor

• Patients with bleeding disorders