Impact of Vitamin D Therapies on Chronic Kidney Disease

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This investigation will consist of a prospective study utilizing two separate populations of patients with 25(OH)D deficiency, one population with chronic kidney disease (CKD) and one with normal renal function.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kansas Medical Center
• Treatments: Calcitriol; Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Chronic kidney disease w/GFR<35ml/min

• Nutritional vitamin D deficiency, defined as 25(OH)D < 25ng/ml

• Secondary hyperparathyroidism, PTH>75pg/mL

Exclusion Criteria:

• Active infection

• Recent hospitalization for acute illness (within last month)

• Refusal to study participation

• History of chronic inflammatory disease process (i.e. inflammatory bowel, rheumatoid arthritis, SLE, etc.)

• Allergy to cholecalciferol or calcitriol

• History of parathyroidectomy

• Functional renal transplant within 5 years

• Current treatment with immunosuppressant medications

• Noncompliance with prescribed medications