Impact of a Fourth Hexavalent Vaccine After Hematopoietic Stem Cell Transplantation
Status:
Unknown status
Trial end date:
2021-05-01
Target enrollment:
Participant gender:
Summary
It is recommended for patients who underwent an hematopoietic stem cell transplantation to
receive 6 months after the graft 3 injections of hexavalent vaccine (diphteria-tetanus-
poliomyelitis-pertussis-Hib-HBV) within 2 months followed by a booster dose one month after.
The patients included in the study will have a measure of their antibody level against 5
pathogens (diphteria toxin, tetanus toxin, Haemophilus influenza b, hepatitis B virus,
poliomyelitis virus) one month after the 3rd injection of hexavalent vaccine. If the antibody
response is not sufficient, they will be randomized for a 4th dose in the following month.
The antibody response will be again measured one month after the 1 year booster dose.
Phase:
Phase 3
Details
Lead Sponsor:
University Hospital, Grenoble
Collaborators:
Centre Hospitalier Universitaire de Besancon Centre Hospitalier Universitaire de Nice University Hospital of Saint-Etienne University Hospital, Clermont-Ferrand