Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC

• Status: Terminated
• Trial end date: 2020-11-30
• Target enrollment: 0
• Participant gender: All

Summary

The objective of our PILOT study is to evaluate the impact of a controlled (monitored) randomized anesthesia during cytoreductive surgery with HIPEC to oxaliplatin in order to treat adenocarcinomas of colorectal origin. The combination of NOL monitoring, BIS monitoring and continuous hemodynamic monitoring (FloTrac EV1000 system) can improve patient safety by reducing the length of hospital stay by decreasing total hypnotic doses and intraoperative opioids and side effects following anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ciusss de L'Est de l'Île de Montréal
• Treatments: Anesthetics; Desflurane; Remifentanil

Criteria

Inclusion Criteria:

• ASA status I, II or III

• Patients older than 18 years

• HIPEC for bowel surgery with oxaliplatin + dextrose 5% for a duration of 30 min

• Duration and type of surgery requiring an epidural analgesia via an epidural catheter placed and tunnelled prior the general anesthesia induction and an arterial line placed after induction of general anesthesia.

Exclusion Criteria:

• Any allergy to one drug used in our anesthesia or HIPEC protocol

• Any contra-indication or patient's refusal for epidural placement

• Chronic arrhythmic cardiac conditions

• Chronic pain with use of opioids more than 3 times per week for 4 weeks

• Bowel occlusion

• Physical/mental incapacities

• Unexpected difficult airway requesting excessive, possibly painful airway manipulations.

• Epidural failure