Impact of isoQUercetin and Aspirin on Platelet Function

• Status: Withdrawn
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate the effect of acute isoquercetin supplementation, aspirin, and isoquercetin/aspirin combination on platelet aggregation, blood pressure and vasculat stiffness (eg digital volume pulse), as well as investigating the plasma accumulation and urine excretion profiles of quercetin.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Reading
• Collaborators: Biotechnology and Biological Sciences Research Council; Quercegen Pharmaceuticals
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Plasma TAG (triacylglycerol) < 4.0 mmol/l

• Body mass index (BMI) between 18-35 kg/m2

• Total cholesterol (TC): <7 mmol/l

• Systolic blood pressure <160 mmHg and diastolic blood pressure <100 mmHg

• Consume less than 5 portions of fruit/vegetables per day

• Male

Exclusion Criteria:

• Suffered a myocardial infarction/stroke in the past 12 months

• Diabetic (diagnosed as fasting blood glucose >7 mmol/l) or suffer from other endocrine disorders

• Suffering from renal or bowel disease or have a history of cholestatic liver or pancreatitis

• On drug treatment for hyperlipidaemia, hypertension, inflammation or hypercoagulation

• History of alcohol abuse

• Planning or on a weight reducing regime

• Undertake vigorous exercise more than 3 times a week

• Taking nutritional supplements (e.g. fish oil, calcium)

• Taking flavonoid supplements

• Suffering from hayfever

• Taking any, or intolerant to, NSAIDS including aspirin

• On any medication, prescribed or not prescribed (or willing to abstain from these during period of study as well as prior 2 week washout period)

• Using any recreational drugs

• Vegan

• Intolerant/allergic to nuts, wheat, dairy

• Intolerant/allergic to aspirin

• On, or have taken antibiotics in the last 2 months

• Had surgery in the last 3 months

• Smokers, or have smoked in the last month

• Using e-cigarettes

• Anaemic: haemoglobin <12.5 g/dl

• History of gastric ulcers

• Female