Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical
underlying placental pathology revealing small placentas and maldevelopment of the decidual
blood vessels, suggesting under-perfusion from the maternal circulation. Since nitric oxide
(NO) donors can improve decreased uteroplacental perfusion without any negative effects on
fetal circulation, these may prevent negative pregnancy outcomes in patients at risk.
The aim of this study is to evaluate the effectiveness of the long-lasting NO donor
pentarythrithyltetranitrate (PETN) to reduce the likelihood of adverse pregnancy outcomes
(intrauterine growth retardation / IUGR, perinatal death, placental abruption, and preterm
delivery) in women recognized to be at risk for this outcome by abnormal uterine flow in mid
gestation.