Impact of the Use of Zinc in the Prevention of Oral Mucositis in Pediatric Patients With Lymphoblastic Acute Leukemia.
Status:
Terminated
Trial end date:
2020-07-30
Target enrollment:
Participant gender:
Summary
Oral mucositis (OM) is a secondary complication of chemo/radiotherapy, which causes pain,
dysphagia and predisposition to infections, being a frequent reason for hospitalization that
may have an impact on the prognosis of cancer patients. Various interventions for the
prevention of OM have been studied, including the use of zinc, which is a micronutrient that
participates in various cellular functions and in wound repair, while showing a reduction in
the incidence and severity of MO, so the purpose of the present study is to evaluate the
impact of the use of zinc in the prevention of oropharyngeal mucositis in pediatric patients
with acute lymphoblastic leukemia in chemotherapy, comparing it with the use of placebo.
Hypothesis: The use of zinc reduces the incidence and severity of OM in pediatric patients
with ALL in chemotherapy compared to the control group.