Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management
Status:
Unknown status
Trial end date:
2019-05-01
Target enrollment:
Participant gender:
Summary
Prevalence of osteoarthritis increases every year, as a chronic and progressive disease.
Osteoarthritis also gives many negative impacts in socio-economic life. Current management of
osteoarthritis only aimed to relieve pain but not to resolve the degeneration of cartilage.
Mesenchymal stem cell is one kind of adult stem cell that has potency in tissue engineering.
Sources of mesenchymal stem cell are bone marrow, adipose tissue and umbilical cord.
Researchers want to explore the potential of umbilical cord as the source of allogeneic MSC,
because the gaining process of MSC is not invasive. Some countries have started some In vitro
studies, Animal studies, and human research, but in Indonesia the study of mesenchymal stem
cell implantation from umbilical cord in genu osteoarthritis management has not been
reported. This study will be held into two years in Cipto Mangunkusumo Hospital and include 9
participants minimally. The researcher also compares the efficacy and safety of MSC
implantation from umbilical cord applied to genu osteoarthritis with synovial artificial and
recombinant human growth hormone therapy.