Implementation of a Pain Management Protocol for Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2019-01-14
• Target enrollment: 0
• Participant gender: All

Summary

Study question: Is there an ideal combination of intraoperative long acting analgesics (periarticular infiltration (PI), femoral nerve block (FB) and intrathecal opioids (IO)) to optimize post-operative functional recovery, decrease overall narcotic consumption and enable faster 'readiness to discharge' for patients undergoing primary total knee replacement (TKR)?

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Health Sciences North Research Institute
• Collaborator: Northern Ontario Academic Medicine Association
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Fentanyl; Ketorolac; Ketorolac Tromethamine; Racepinephrine

Criteria

Inclusion Criteria:

• Age 18 years or older

• primary total knee replacement for osteoarthritis

• agrees to a spinal anesthetic for TKR

Exclusion Criteria:

• History of chronic pain or opioid tolerance (individuals requiring equivalent of 1 mg or more intravenous or 3 mg or more oral morphine per hour for greater than 1 month)

• general anesthetic for TKR

• major neurological deficit

• allergy to local anesthetic

• allergy to morphine or hydromorphone, anti-inflammatory, acetaminophen

• renal insufficiency

• liver failure