Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production. This is done in 10 healthy men on calorie restriction on 4 study days with fat and skeletal muscle biopsies.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Treatments: Hormones

Criteria

Inclusion Criteria:

• healthy lean men

• age >18

Exclusion Criteria:

• metabolic disturbances

• alcohol drug abuse

• malign disease: current or previous